Specification
Certificate of analysis
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Verify your vial →Semax
ACTH(4-10) analogue, Met-Glu-His-Phe-Pro-Gly-Pro
A heptapeptide analogue of the ACTH(4-10) fragment with the melanocortin activity removed — studied for neurotrophic and neuroprotective effects.
What the literature describes
Semax is ACTH(4-10) with a C-terminal Pro-Gly-Pro extension that confers stability while stripping the hormonal activity of the parent fragment. A single application in rats has been reported to raise hippocampal BDNF protein about 1.4-fold with a roughly 3-fold increase in exon-III BDNF mRNA and a 1.6-fold increase in trkB tyrosine phosphorylation. Other published work reports prevention of enhanced nitric oxide generation in cerebral cortex under incomplete global ischaemia, and antidepressant-like effects in chronic unpredictable stress models.
Available sizes & pricing
Price is per single sealed vial, in USD. Buying several — volume pricing.
| Vial strength | Price | |
|---|---|---|
| 5mg | $78.40 | Order 5mg |
| 10mg | $114.80 | Order 10mg |
Published research
Links open peer-reviewed sources on PubMed. These are provided so you can read the primary literature yourself. Citing a study is not a claim that this compound is safe or effective for any use in humans.
- Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampusPubMed
- Comparison of the temporary dynamics of NGF and BDNF gene expression under Semax actionPubMed
- Semax prevents enhanced nitric oxide generation in cerebral cortex of rats with incomplete global ischemiaPubMed
- Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan IIPubMed
- All indexed literature on Semax (PubMed search)PubMed search
Research areas
Studied in the same area
Cerebrolysin
A porcine-brain-derived peptide preparation studied extensively in neurorestoration literature.