Specification
Purity>99% (HPLC + MS)
FormLyophilised powder
Supplied asSingle sealed vial
Storage-20 °C, dark, sealed
Reconstituted2–8 °C
Certificate of analysis
Scan the QR code on your vial, or type the batch number, and you get the analytical data for the exact vial you received.
Verify your vial →KPV
Lys-Pro-Val, α-MSH(11-13)
The C-terminal tripeptide of alpha-melanocyte-stimulating hormone, carrying most of the parent hormone's anti-inflammatory activity in a three-residue package.
Research use only. This compound is supplied for laboratory research. It is not a medicine or supplement, is not approved for human use, and no dosing guidance for humans is offered here or by our team. Handle under appropriate laboratory conditions. Full disclaimer →
What the literature describes
Alpha-MSH is an ancient anti-inflammatory peptide found in barrier organs such as gut and skin. Published dissection studies have traced the bulk of its anti-inflammatory activity to the C-terminal tripeptide KPV. The reported mechanism is distinct from that of the core MSH sequence: KPV appears unlikely to signal through melanocortin receptors and is instead described as acting via inhibition of IL-1β function and NF-κB nuclear translocation. In murine dextran-sulfate colitis, alpha-MSH administration reduced faecal blood and weight loss relative to placebo, and colonic lesions were reduced in both acute and chronic rat colitis models.
Available sizes & pricing
Price is per single sealed vial, in USD. Buying several — volume pricing.
| Vial strength | Price | |
|---|---|---|
| 5mg | $78.40 | Order 5mg |
| 10mg | $106.40 | Order 10mg |
Published research
Links open peer-reviewed sources on PubMed. These are provided so you can read the primary literature yourself. Citing a study is not a claim that this compound is safe or effective for any use in humans.
- Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptidesPubMed
- Melanocortin-derived tripeptide KPV has anti-inflammatory potentialPubMed
- Alpha-MSH related peptides: a new class of anti-inflammatory and immunomodulating drugsPubMed
- Terminal signal: anti-inflammatory effects of u03b1-MSH related peptides beyond the pharmacophorePubMed
- Published literature on KPV (PubMed)PubMed search
Research areas
Studied in the same area
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